Vanillin → Curcumin

Participants

Reaction Steps

British patent No. 914 047 (publ. 28.12.62) describes the condensation of vanillin with acetylacetone in the presence of 2 mole equivalents of trialkyl borates and 0.35 molequivalents boric oxide to give curcumin with yields from 16-80% of the theory. Best results (80% yield) at room temperature were obtained in ethyl acetate as solvent with 2 molequivalents tri-isopropyl borate in the presence of 0.35 molequivalent of boric anhydride and 0.1 molequivalent butylamine (Pabon, H. J. J., Recueil 83, 379-386 [1964]). However, the purity of the curcumin is not mentioned.

Provenance & Evidence