Trifluoroacetic acid methylene chloride → HCID 67246126, compound

HRID 2425755Notes

Reaction equation

HRID 2425755 reaction equation
[CH:1]([N:4]1[C:13]2[C:8](=[C:9]([CH3:14])[CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:15]([NH:17][CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([CH:25]([CH3:33])[C:26]([O:28]C(C)(C)C)=[O:27])[CH2:21][CH2:20]2)=[O:16])[C:5]1=[O:34])([CH3:3])[CH3:2].FC(F)(F)C(O)=O.[Cl:42]CCl>>[ClH:42].[CH:1]([N:4]1[C:13]2[C:8](=[C:9]([CH3:14])[CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:15]([NH:17][CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([CH:25]([CH3:33])[C:26]([OH:28])=[O:27])[CH2:21][CH2:20]2)=[O:16])[C:5]1=[O:34])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 67246672HCID 67246672, compound

Product 1

HCID 67246126HCID 67246126, compound

Procedure

A solution of tert-butyl 2-[4-({[(1-isopropyl-5-methyl-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}methyl)piperidin-1-yl]propanoate (299 mg, 0.64 mmol, step 1) in trifluoroacetic acid/dichloromethane (1:1, 20 mL) was stirred at room temperature for 16 h. Then, the solvent was removed in vacuo. To the residue was added 10% hydrogen chloride in methanol, and evaporated in vacuo. This was repeated three times to give 295 mg (quant.) of the title compound as a yellow amorphous.

Workup

  1. customThen, the solvent was removed in vacuo
  2. additionTo the residue was added 10% hydrogen chloride in methanol
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-29ffad05ef8c4395802bfca9f4c0f733
Source dataset
uspto-grants-2011_06
Patent number
US07964727B2

Reaction notes

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