Trifluoroacetic acid methylene chloride → HCID 67246126, compound

Participants

Reaction Steps

A solution of tert-butyl 2-[4-({[(1-isopropyl-5-methyl-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}methyl)piperidin-1-yl]propanoate (299 mg, 0.64 mmol, step 1) in trifluoroacetic acid/dichloromethane (1:1, 20 mL) was stirred at room temperature for 16 h. Then, the solvent was removed in vacuo. To the residue was added 10% hydrogen chloride in methanol, and evaporated in vacuo. This was repeated three times to give 295 mg (quant.) of the title compound as a yellow amorphous.

Provenance & Evidence