Hydrochloric Acid → HCID 59822466, compound

Participants

Reaction Steps

A mixture of ethyl 1-isopropyl-5-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate (15.0 g, 54.9 mmol), 2N aqueous sodium hydroxide (41 mL, 82 mmol), and ethanol (150 mL) was stirred at room temperature for 2 h. Then, 2N aqueous hydrochloride (41 mL, 82 mmol) was added, and the white precipitate was collected by filtration. This solid was washed with water to give 12.6 g (93%) of the title compound as a pale yellow solid.

Provenance & Evidence