Hydrochloric Acid → HCID 59822466, compound

HRID 2425763Notes

Reaction equation

HRID 2425763 reaction equation
[CH:1]([N:4]1[C:13]2[C:8](=[C:9]([CH3:14])[CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:15]([O:17]CC)=[O:16])[C:5]1=[O:20])([CH3:3])[CH3:2].[OH-].[Na+].Cl>C(O)C>[CH:1]([N:4]1[C:13]2[C:8](=[C:9]([CH3:14])[CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:15]([OH:17])=[O:16])[C:5]1=[O:20])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59822486HCID 59822486, compound

Product 1

HCID 59822466HCID 59822466, compoundYield 93.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl 1-isopropyl-5-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate (15.0 g, 54.9 mmol), 2N aqueous sodium hydroxide (41 mL, 82 mmol), and ethanol (150 mL) was stirred at room temperature for 2 h. Then, 2N aqueous hydrochloride (41 mL, 82 mmol) was added, and the white precipitate was collected by filtration. This solid was washed with water to give 12.6 g (93%) of the title compound as a pale yellow solid.

Workup

  1. filtrationthe white precipitate was collected by filtration
  2. washThis solid was washed with water

Sources & evidence

ORD record
ord-5f082d73c31a4d39b0ff5c925e7f12ff
Source dataset
uspto-grants-2011_06
Patent number
US07964727B2

Reaction notes

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