1,3-Difluorobenzene → HCID 67148212, compound

HRID 2425853Notes

Reaction equation

C([Li])CCC.[F:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=1.[N+:14]([C:17]1[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:18]=1[CH:19]=[O:20])([O-:16])=[O:15].[Cl-].[NH4+]>CCCCCC.O1CCCC1.C(OCC)C>[F:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[C:8]=1[CH:19]([C:18]1[CH:21]=[CH:22][CH:23]=[C:24]([O:25][CH3:26])[C:17]=1[N+:14]([O-:16])=[O:15])[OH:20]

Participants

Conditions

Temperature: -70 °C

Procedure

77.5 ml of a 1.6M solution of n-butyllithium (1.5 eq.) in hexane are added dropwise in order to maintain a temperature of less than or equal to −70° C. to a solution of 12.3 ml of 1,3-difluorobenzene (1.5 eq.) in 150 ml of tetrahydrofuran over 1 hour. After an additional 1 hour at −70° C., a solution of 15 g of 2-nitro-3-methoxybenzaldehyde in tetrahydrofuran is added over 1 hour still at −70° C. The reaction medium is stirred for 4 hours at −70° C. and then brought to a temperature of −5° C. over 1 hour. The reaction medium is then diluted by adding diethyl ether and then slowly hydrolyzed with a saturated aqueous solution of ammonium chloride. After decantation, the organic phase is washed with water and then dried over anhydrous sodium sulfate. The residue is chromatographed on silica gel, eluting with a dichloromethane/cyclohexane mixture (1/1) (v/v) in order to obtain 13.4 g of the expected product.

Workup

waitbrought to a temperature of −5° C. over 1 hour
additionThe reaction medium is then diluted
washAfter decantation, the organic phase is washed with water
dry with materialdried over anhydrous sodium sulfate
customThe residue is chromatographed on silica gel
washeluting with a dichloromethane/cyclohexane mixture (1/1) (v/v) in order

Sources & evidence

ORD record: ord-c2d3e1ce8c1a49cb86584afdb285a719
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07968534B2

Reaction notes

Loading…