Pyridine → HCID 67148767, compound

HRID 2425858Notes

Reaction equation

HRID 2425858 reaction equation
N1C=CC=CC=1.[CH3:7][O:8][C:9]1[CH:10]=[C:11]([S:17](Cl)(=[O:19])=[O:18])[CH:12]=[CH:13][C:14]=1[O:15][CH3:16].[Cl:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[C:24]([CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[CH:23]=1>O1CCCC1.O>[Cl:21][C:22]1[CH:28]=[CH:27][C:25]([NH:26][S:17]([C:11]2[CH:12]=[CH:13][C:14]([O:15][CH3:16])=[C:9]([O:8][CH3:7])[CH:10]=2)(=[O:19])=[O:18])=[C:24]([CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[CH:23]=1

Participants

6

Reactant 3

HCID 1049PyridineHCID 27341833,4-Dimethoxybenzenesulfonyl chlorideHCID 14005180HCID 14005180, compound

Product 1

HCID 67148767HCID 67148767, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

0.7 ml of pyridine and then 2.27 g of 3,4-dimethoxybenzenesulfonyl chloride are successively added at room temperature to 1.86 g of 4-chloro-2-(pyridin-2-ylmethyl)aniline in solution in 20 ml of tetrahydrofuran. After 72 hours at room temperature, the reaction medium is taken up in water and extracted with ethyl acetate, the organic phase is dried over anhydrous sodium sulfate and concentrated in order to obtain 2.12 g of the expected product.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialthe organic phase is dried over anhydrous sodium sulfate
  3. concentrationconcentrated in order

Sources & evidence

ORD record
ord-c960307df5bc44e3a8e52c808174c6d2
Source dataset
uspto-grants-2011_06
Patent number
US07968534B2

Reaction notes

Loading…