2,5-Dimethylpyrrolidine → HCID 59341129, compound

HRID 2425877Notes

Reaction equation

HRID 2425877 reaction equation
Cl[C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14])[N:5]=[CH:4][N:3]=1.[CH3:15][CH:16]1[CH2:20][CH2:19][CH:18]([CH3:21])[NH:17]1>>[CH3:15][CH:16]1[CH2:20][CH2:19][CH:18]([CH3:21])[N:17]1[C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14])[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 960342,5-DimethylpyrrolidineHCID 593411204-Chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine

Product 1

HCID 59341129HCID 59341129, compoundYield 46.4%

Procedure

0.2 g of 4-chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine and 0.2 g of 2,5-dimethylpyrrolidine were mixed and left for 13 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.12 g of 4-(2,5-dimethyl-1-pyrrolidinyl)-5-fluoro-6-(2-pentynyloxy)pyrimidine (hereinafter, referred to as Compound (13)).

Sources & evidence

ORD record
ord-f8cdef6c1f4a458cb9df7ee6e2669f47
Source dataset
uspto-grants-2011_06
Patent number
US07968537B2

Reaction notes

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