Hydrazine hydrate (1:1) → HCID 57688128, compound

HRID 2425944Notes

Reaction equation

HRID 2425944 reaction equation
[CH3:1][N:2]1[C:6]([CH2:7][NH:8][C:9]([C:11]2[S:15][C:14]([C:16]([O:18]C)=O)=[CH:13][CH:12]=2)=[O:10])=[CH:5][CH:4]=[N:3]1.O.[NH2:21][NH2:22]>CO>[CH3:1][N:2]1[C:6]([CH2:7][NH:8][C:9]([C:11]2[S:15][C:14]([C:16]([NH:21][NH2:22])=[O:18])=[CH:13][CH:12]=2)=[O:10])=[CH:5][CH:4]=[N:3]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67087360HCID 67087360, compound

Product 1

HCID 57688128HCID 57688128, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 5-(1-methyl-1H-pyrazol-5-ylmethylcarbamoyl)thiophene-2-carboxylate (0.25 g, 0.90 mmol) in methanol (2.5 mL) was stirred with hydrazine monohydrate (0.17 mL, 3.6 mmol) at 70° C. for 3.5 hours. The precipitated solid was recovered by filtration, washed with chloroform and dried to give the desired product, 5-hydrazinocarbonylthiophene-2-carboxylic acid (1-methyl-1H-pyrazol-5-ylmethyl)amide (yield 49%).

Workup

  1. filtrationThe precipitated solid was recovered by filtration
  2. washwashed with chloroform
  3. customdried

Sources & evidence

ORD record
ord-0c229059a5a04d19b33bd3347198b2f1
Source dataset
uspto-grants-2011_06
Patent number
US07968542B2

Reaction notes

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