HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → HCID 57688134, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 67087181 | HCID 67087181 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 57688134 | HCID 57688134 | 72% |
Reaction Steps
Methyl 5-(5-methylpyrazin-2-ylmethylcarbamoyl)thiophene-2-carboxylate (304 mg, 1.04 mmol) in methanol (3 mL) was stirred with hydrazine monohydrate at 60° C. for 12 hours. After addition of chloroform, it was stirred at room temperature for 5 hours. The precipitated solid was recovered by filtration to give the desired product, 5-hydrazinocarbonylthiophene-2-carboxylic acid (5-methylpyrazin-2-ylmethyl)amide (yield 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968542B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-358d2952a6f949d18d2145c8182fa160 |
| Source note | uspto-grants-2011_06 |