Chloroform → HCID 57688134, compound

HRID 2425945Notes

Reaction equation

HRID 2425945 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][C:5]([CH2:8][NH:9][C:10]([C:12]2[S:16][C:15]([C:17]([O:19]C)=O)=[CH:14][CH:13]=2)=[O:11])=[N:6][CH:7]=1.O.[NH2:22][NH2:23].C(Cl)(Cl)Cl>CO>[CH3:1][C:2]1[N:3]=[CH:4][C:5]([CH2:8][NH:9][C:10]([C:12]2[S:16][C:15]([C:17]([NH:22][NH2:23])=[O:19])=[CH:14][CH:13]=2)=[O:11])=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 24654Hydrazine hydrate (1:1)HCID 67087181HCID 67087181, compound

Product 1

HCID 57688134HCID 57688134, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 5-(5-methylpyrazin-2-ylmethylcarbamoyl)thiophene-2-carboxylate (304 mg, 1.04 mmol) in methanol (3 mL) was stirred with hydrazine monohydrate at 60° C. for 12 hours. After addition of chloroform, it was stirred at room temperature for 5 hours. The precipitated solid was recovered by filtration to give the desired product, 5-hydrazinocarbonylthiophene-2-carboxylic acid (5-methylpyrazin-2-ylmethyl)amide (yield 72%).

Workup

  1. filtrationThe precipitated solid was recovered by filtration

Sources & evidence

ORD record
ord-358d2952a6f949d18d2145c8182fa160
Source dataset
uspto-grants-2011_06
Patent number
US07968542B2

Reaction notes

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