Potassium Hydroxide → HCID 73174863, compound

HRID 2425948Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2[S:14][CH:13]=[C:12]([C:15](=[N:17][NH:18][C:19]([C:21]3[S:22][C:23]([C:26]([N:28]4[CH2:33][CH2:32][N:31]([CH:34]([CH3:36])[CH3:35])[CH2:30][CH2:29]4)=[O:27])=[CH:24][CH:25]=3)=[O:20])[CH3:16])[C:11]=2[OH:37])[CH:6]=[CH:7][C:8]=1[Cl:9].[OH-].[K+]>CO>[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2[S:14][CH:13]=[C:12]([C:15](=[N:17][NH:18][C:19]([C:21]3[S:22][C:23]([C:26]([N:28]4[CH2:29][CH2:30][N:31]([CH:34]([CH3:35])[CH3:36])[CH2:32][CH2:33]4)=[O:27])=[CH:24][CH:25]=3)=[O:20])[CH3:16])[C:11]=2[OH:37])[CH:6]=[CH:7][C:8]=1[Cl:9]

Participants

Conditions

Temperature: 50 °C

Procedure

5-(4-Isopropylpiperazine-1-carbonyl)thiophene-2-carboxylic acid {1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidene}hydrazide hydrochloride (14 mg, 0.025 mmol) was suspended in methanol (2.7 mL), and 0.1 M potassium hydroxide in methanol (0.24 mL) and methanol (5.4 mL) were added. The suspension was heated at 50° C. and concentrated to dryness under reduced pressure to give the desired product (yield 100%).

Workup

concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record: ord-4ce1a6b4fb7641e9a20beb7663e5d535
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07968542B2

Reaction notes

Loading…