2-(3,4-Dichlorophenyl)-3-hydroxy-4-(methylcarbonyl)thiophene → HCID 73224738, compound

HRID 2425950Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([C:15]([CH3:17])=O)[C:13]=2[OH:14])[CH:5]=[CH:6][C:7]=1[Cl:8].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([NH:24][C:25]([C:27]2[S:28][C:29]([C:32]([NH:34][NH2:35])=[O:33])=[CH:30][CH:31]=2)=[O:26])[CH:19]=1>CS(C)=O>[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([NH:24][C:25]([C:27]2[S:28][C:29]([C:32]([NH:34][N:35]=[C:15]([C:12]3[C:13]([OH:14])=[C:9]([C:4]4[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=4)[S:10][CH:11]=3)[CH3:17])=[O:33])=[CH:30][CH:31]=2)=[O:26])[CH:19]=1

Participants

Conditions

Temperature: 100 °C

Procedure

28 mg of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene and 26 mg of 5-hydrazinocarbonylthiophene-2-carboxylic acid 3-pyridylamide were dissolved in 2 mL of dimethyl sulfoxide and heated at 100° C. for 18 hours, and the solvent was evaporated. Recrystallization from chloroform-diethyl ether gave the desired product (yield 94%).

Workup

customthe solvent was evaporated
customRecrystallization from chloroform-diethyl ether

Sources & evidence

ORD record: ord-b24acaeea6b34f8ebf1fbe85654e8a08
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07968542B2

Reaction notes

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