5-Hydrazinocarbonylthiophene-2-carboxylic acid methyl-2-picolylamide → 5-{1-[5-(4-Trifluoromethylphenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxylic Acid methyl-2-picolylamide

HRID 2425952Notes

Reaction equation

HRID 2425952 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][CH:11]=[C:12]([C:15]([CH3:17])=O)[C:13]=2[OH:14])=[CH:5][CH:4]=1.[CH3:20][N:21]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=1)[C:22]([C:24]1[S:25][C:26]([C:29]([NH:31][NH2:32])=[O:30])=[CH:27][CH:28]=1)=[O:23]>>[CH3:20][N:21]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=1)[C:22]([C:24]1[S:25][C:26]([C:29]([NH:31][N:32]=[C:15]([C:12]2[C:13]([OH:14])=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([C:2]([F:19])([F:18])[F:1])=[CH:4][CH:5]=3)[S:10][CH:11]=2)[CH3:17])=[O:30])=[CH:27][CH:28]=1)=[O:23]

Participants

3

Reactant 2

HCID 576881325-Hydrazinocarbonylthiophene-2-carboxylic acid methyl-2-picolylamideHCID 602067891-{4-Hydroxy-5-[4-(trifluoromethyl)phenyl]thiophen-3-yl}ethan-1-one

Product 1

HCID 732249795-{1-[5-(4-Trifluoromethylphenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxylic Acid methyl-2-picolylamide

Procedure

Synthesis was carried out in the same manner as in Synthetic Example 7 by using 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene and 5-hydrazinocarbonylthiophene-2-carboxylic acid methyl-2-picolylamide prepared in Reference Synthetic Example 10.

Workup

  1. customSynthesis
  2. customprepared in Reference Synthetic Example 10

Sources & evidence

ORD record
ord-1a0524ab76a54f60aeaeeb772ad06fe3
Source dataset
uspto-grants-2011_06
Patent number
US07968542B2

Reaction notes

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