Trifluoroacetic acid → 4-(2,6-Dimethoxyphenyl)-L-phenyalanine Methyl Ester Trifluoroacetic Acid Salt

HRID 2426091Notes

Reaction equation

HRID 2426091 reaction equation
[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[C:25]([O:26][CH3:27])=[CH:24][CH:23]=[CH:22][C:21]=2[O:28][CH3:29])=[CH:16][CH:15]=1)[NH:5]C(OC(C)(C)C)=O.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>C(Cl)Cl>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[C:25]([O:26][CH3:27])=[CH:24][CH:23]=[CH:22][C:21]=2[O:28][CH3:29])=[CH:18][CH:19]=1)[NH2:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 10309931N-tert-butoxycarbonyl-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester

Product 1

HCID 672631064-(2,6-Dimethoxyphenyl)-L-phenyalanine Methyl Ester Trifluoroacetic Acid Salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A methylene chloride solution of N-tert-butoxycarbonyl-4-(2,6-dimethoxyphenyl)-L-phenyalanine methyl ester was treated with trifluoroacetic acid for six hours at room temperature. Concentration of the volatiles yielded the title compound.

Sources & evidence

ORD record
ord-f0fc13658623405bb529c8f5f6239e7a
Source dataset
uspto-grants-2011_06
Patent number
US07968547B2

Reaction notes

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