HCID 18449406, compound → HCID 18449408, compound

HRID 2426151Notes

Reaction equation

HRID 2426151 reaction equation
[CH2:1]([N:8]1[C:12]2([CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([N+:21]([O-])=O)[CH:18]=3)[CH2:13]2)[C:11](=[O:24])[NH:10][C:9]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.CO.[Pd]>[NH2:21][C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][CH:16]=1)[CH2:13][C:12]1([C:11](=[O:24])[NH:10][C:9](=[O:25])[N:8]1[CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:20]2

Participants

5

Reactant 1

HCID 18449406HCID 18449406, compound

Product 1

HCID 18449408HCID 18449408, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of (±)-3-benzyl-5′-nitro-spiro[imidazolidine-4,2′-indane]-2,5-dione from Step C (80 mg, 0.24 mmol) in EtOAc (1.5 mL) and MeOH (1.5 mL) was added 10% Pd/C (5 mg) and the reaction mixture was stirred vigorously under hydrogen (ca. 1 atm). After 18 h, the catalyst was filtered off and the filtrate was concentrated to yield the title compound. MS: m/z=308 (M+1).

Workup

  1. filtrationthe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-a737961c1d834d6dac983106ed707eee
Source dataset
uspto-grants-2011_06
Patent number
US07968540B2

Reaction notes

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