HCID 57863157, compound → HCID 57863140, compound

HRID 2426284Notes

Reaction equation

HRID 2426284 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:19]=[CH:18][C:17]4[C:12](=[CH:13][CH:14]=[C:15]([N+:20]([O-])=O)[CH:16]=4)[N:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1>CO.C1COCC1.[Pd]>[NH2:20][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]([C:8]1[CH:7]=[CH:6][C:5]3[O:1][CH2:2][O:3][C:4]=3[CH:9]=1)[CH:19]=[CH:18]2

Participants

4

Reactant 1

HCID 57863157HCID 57863157, compound

Product 1

HCID 57863140HCID 57863140, compoundYield 73%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

10% Pd/C (0.29 g, 0.27 mmol) is added to 2-(1,3-benzodioxol-5-yl)-6-nitroquinoline (2.0 g, 6.80 mmol) in methanol/THF (80 ml/80 ml). The mixture is hydrogenated at r.t. for 2 hours. The catalyst is filtered off and the filtrate is concentrated to afford 1.31 g (73%) of the titled product.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-8ac3c150816c4807a7fd4cc4376a2c04
Source dataset
uspto-grants-2011_06
Patent number
US07968558B2

Reaction notes

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