Trifluoroacetic acid → HCID 67148013, compound

HRID 2426327Notes

Reaction equation

HRID 2426327 reaction equation
[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][C@@H:16]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:32]=[C:31]([CH2:33][NH:34][CH2:35]C(OC(C)(C)C)=O)[S:30][CH:29]=2)=[CH:24][CH:23]=1)[C:17]([O:19][CH3:20])=[O:18])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][C@@H:16]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:32]=[C:31]([CH2:33][NH:34][CH3:35])[S:30][CH:29]=2)=[CH:24][CH:23]=1)[C:17]([O:19][CH3:20])=[O:18])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67148549HCID 67148549, compound

Product 1

HCID 67148013HCID 67148013, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.9 g (5 mmol) of methyl 2(S)-(2-benzoylphenylamino)-3-(4-{5-[(tert-butoxycarbonylmethylamino)methyl]thiophen-3-yl}phenyl)propanoate are placed in 30 ml of dichloromethane and 2.5 ml (32 mmol) of trifluoroacetic acid. After stirring at room temperature for 18 hours, the reaction medium is evaporated to dryness. 2.4 g (100%) of methyl 2(S)-(2-benzoylphenylamino)-3-[4-(5-methylaminomethylthiophen-3-yl)phenyl]propanoate are obtained.

Workup

  1. customthe reaction medium is evaporated to dryness

Sources & evidence

ORD record
ord-5b9e60bc97da4ca5a7fbd59703e2101f
Source dataset
uspto-grants-2011_06
Patent number
US07968560B2

Reaction notes

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