反应详情

A solution of 4-(4-chloro-2-methyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.26 g, 0.837 mmol) in dichloromethane cooled at 0° C. was treated with trifluoroacetic acid (20%) and warmed to room temperature and stirred for 2 hours. The reaction mixture was concentrated in vacuo, diluted with ethyl acetate and free based with 10% aqueous sodium bicarbonate. The organics were separated and dried over sodium sulfate and concentrated. The product was used without further purification ESI-MS m/z: 211 (M+1), UV retention time: 1.25 min.

1. concentrationThe reaction mixture was concentrated in vacuo
2. additiondiluted with ethyl acetate
3. customThe organics were separated
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customThe product was used without further purification ESI-MS m/z