反应详情

A solution of 4-(4-chloro-2-cyano-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.32 g, 1 mmol) in dichloromethane cooled at 0° C. was treated with trifluoroacetic acid (20%) and warmed to room temperature and stirred for 2 h. The reaction mixture was concentrated in vacuo, diluted with ethyl acetate and free based with 10% aqueous sodium bicarbonate. The organic layers were separated and dried over sodium sulfate and concentrated in vacuo. The product used without further purification.

1. concentrationThe reaction mixture was concentrated in vacuo
2. additiondiluted with ethyl acetate
3. customThe organic layers were separated
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated in vacuo
6. customThe product used without further purification