HCID 66997518, compound → HCID 66997561, compound

HRID 2426445Notes

Reaction equation

HRID 2426445 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[F:27])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:22])[CH:10]=[N+:11]([O-])[C:12]=2[C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:7]1=[O:23]>C(OC(=O)C)(=O)C>[C:16]([O:18][C:10]1[N:11]=[C:12]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:13]2[CH2:14][CH2:15][N:6]([CH2:5][C:4]3[CH:24]=[CH:25][C:26]([F:27])=[C:2]([Cl:1])[CH:3]=3)[C:7](=[O:23])[C:8]=2[C:9]=1[O:22][C:9](=[O:22])[CH3:8])(=[O:17])[CH3:12]

Participants

3

Reactant 1

HCID 66997518HCID 66997518, compound

Product 1

HCID 66997561HCID 66997561, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate 2-oxide (23 g, 58 mol) in acetic anhydride (400 mL) was heated under nitrogen at 100° C. for one hour. The product mixture was concentrated under vacuum to the title bisacetate and was used in the following step without further purification.

Workup

  1. concentrationThe product mixture was concentrated under vacuum to the title bisacetate
  2. customwas used in the following step without further purification

Sources & evidence

ORD record
ord-f2a8d0b4808b45299a86efd21f1125ac
Source dataset
uspto-grants-2011_06
Patent number
US07968564B2

Reaction notes

Loading…