2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-3-vinyl-1H-indole methanol → 3-Ethyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-1H-indole

HRID 2426510Notes

Reaction equation

HRID 2426510 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[N:5][C:6]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)=[CH:7][C:8]=1[C:9]1(CO)[CH:17]([CH:18]=[CH2:19])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10]1>[Pd]>[CH2:18]([C:17]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][C:9]=1[C:8]1[CH:7]=[C:6]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)[N:5]=[N:4][C:3]=1[O:2][CH3:1])[CH3:19]

Participants

3

Reactant 1

HCID 866120502-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-3-vinyl-1H-indole methanol

Product 1

HCID 230924553-Ethyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-1H-indole

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

12 mg Palladium, 10% on charcoal are added to a solution of 70 mg 2-(3-Methoxy-6-pyridin-4-yl-pyridazin-4-yl)-3-vinyl-1H-indole methanol, and the reaction mixture is stirred under an hydrogen atmosphere for 4 hours. The catalyst is removed by filtration and the solvent by evaporation yielding the product which was used without further purification.

Workup

  1. customThe catalyst is removed by filtration
  2. customthe solvent by evaporation
  3. customyielding the product which
  4. customwas used without further purification

Sources & evidence

ORD record
ord-0920ab515cd948e28e712d481724a39e
Source dataset
uspto-grants-2011_06
Patent number
US07968546B2

Reaction notes

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