反应详情

A solution of [1-(3,5-diisopropoxy-benzyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (3.23 g, 7.95 mmol) in 4 M HCl (100 mL) was stirred at rt for 2 h. The hydrochloric acid was removed under reduced pressure and the crude reaction product extracted from a solution of 1 M NaOH (100 mL) with ethyl acetate (3×100 mL). The combined organic phases were dried over MgSO4 and concentrated by evaporation under reduced pressure yielding 0.78 g (32%) of a colorless oil.

1. customThe hydrochloric acid was removed under reduced pressure
2. customthe crude reaction product
3. extractionextracted from a solution of 1 M NaOH (100 mL) with ethyl acetate (3×100 mL)
4. dry with materialThe combined organic phases were dried over MgSO4
5. concentrationconcentrated by evaporation under reduced pressure