1,1-Dimethylethyl 4-[(2-chloro-6,7-dihydro-5H-cyclopentapyrimidin-4-yl)amino]-1-piperidinecarboxylate → HCID 86618551, compound

HRID 2426564Notes

Reaction equation

HRID 2426564 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:20]3[CH2:21][CH2:22][CH2:23][C:19]=3[N:18]=[C:17]([Cl:24])[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>CO.Cl.O1CCOCC1>[ClH:24].[ClH:24].[Cl:24][C:17]1[N:16]=[C:15]([NH:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[C:20]2[CH2:21][CH2:22][CH2:23][C:19]=2[N:18]=1

Participants

5

Reactant 1

HCID 863463121,1-Dimethylethyl 4-[(2-chloro-6,7-dihydro-5H-cyclopentapyrimidin-4-yl)amino]-1-piperidinecarboxylate

Product 1

HCID 86618551HCID 86618551, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(2-chloro-6,7-dihydro-5H-cyclopentapyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (2.34 g, 6.63 mmol) in MeOH (10 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 253.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-fcf26e1355634a188f297d1e3c698525
Source dataset
uspto-grants-2011_06
Patent number
US07968568B2

Reaction notes

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