4-(7-Chloro-quinazolin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester → (7-Chloro-quinazolin-4-yl)-piperidin-4-yl-amine dihydrochloride

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Reaction Steps

A solution of 4-(7-chloro-quinazolin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (4.33 g, 11.9 mmol) in dioxane (35 mL) and conc. HCl (10 mL) was stirred at rt for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ESP): 263.0 [M+H]+.

Provenance & Evidence