4-(7-Chloro-quinazolin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester → (7-Chloro-quinazolin-4-yl)-piperidin-4-yl-amine dihydrochloride

HRID 2426570Notes

Reaction equation

HRID 2426570 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:24]3[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=3)[N:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>O1CCOCC1.Cl>[ClH:25].[ClH:25].[Cl:25][C:21]1[CH:20]=[C:19]2[C:24]([C:15]([NH:14][CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[N:16][CH:17]=[N:18]2)=[CH:23][CH:22]=1

Participants

4

Reactant 1

HCID 671473374-(7-Chloro-quinazolin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 67147309(7-Chloro-quinazolin-4-yl)-piperidin-4-yl-amine dihydrochloride

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(7-chloro-quinazolin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (4.33 g, 11.9 mmol) in dioxane (35 mL) and conc. HCl (10 mL) was stirred at rt for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ESP): 263.0 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-2688b870f84b4e25a0b45014fc00065b
Source dataset
uspto-grants-2011_06
Patent number
US07968568B2

Reaction notes

Loading…