HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-methyl-N-[1-(4-nitrophenyl)pyrrolidin-3-yl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-(N-Acetyl-N-methylamino)pyrrolidine | HCID 13041130 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-methyl-N-[1-(4-nitrophenyl)pyrrolidin-3-yl]acetamide | HCID 21105631 | — |
Reaction Steps
4-Fluoronitrobenzene (25.0 g) was slowly added to a suspension of N-methyl-N-pyrrolidin-3-ylacetamide (25.2 g) and cesium carbonate (57.6 g) in DMF (300 ml). After 2 hours, the reaction mixture was poured into water, and the resultant precipitate was filtered off with suction. Alternatively, the product can also be extracted with ethyl acetate and purified by chromatography after concentration. This results in the product with the molecular weight of 263.30 (C13H17N3O3): MS (ESI): 264 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968550B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-e431602dcf7f42f685b218c40a12d73d |
| Source note | uspto-grants-2011_06 |