反应详情

4-Fluoronitrobenzene (25.0 g) was slowly added to a suspension of N-methyl-N-pyrrolidin-3-ylacetamide (25.2 g) and cesium carbonate (57.6 g) in DMF (300 ml). After 2 hours, the reaction mixture was poured into water, and the resultant precipitate was filtered off with suction. Alternatively, the product can also be extracted with ethyl acetate and purified by chromatography after concentration. This results in the product with the molecular weight of 263.30 (C13H17N3O3): MS (ESI): 264 (M+H+).

1. filtrationthe resultant precipitate was filtered off with suction
2. extractionAlternatively, the product can also be extracted with ethyl acetate
3. custompurified by chromatography
4. concentrationafter concentration
5. customThis results in the product with the molecular weight of 263.30 (C13H17N3O3)