1,1'-Carbonyldiimidazole → HCID 86594861, compound

HRID 2426611Notes

Reaction equation

HRID 2426611 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:9]2)=[CH:4][CH:3]=1.[C:22]([N:29]1[CH:33]=[CH:32]N=[CH:30]1)(N1C=CN=C1)=[O:23].[Cl:34][C:35]1[CH:40]=[CH:39][C:38]([CH:41]2CCNC[CH2:42]2)=[CH:37][CH:36]=1>>[Cl:34][C:35]1[CH:40]=[CH:39][C:38]([CH:41]2[CH2:42][CH2:30][N:29]([C:22]([NH:1][C:2]3[CH:7]=[CH:6][C:5]([N:8]4[CH2:12][CH2:11][C@H:10]([CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:18])([CH3:20])[CH3:19])[CH2:9]4)=[CH:4][CH:3]=3)=[O:23])[CH2:33][CH2:32]2)=[CH:37][CH:36]=1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 12036134-(4-Chlorophenyl)piperidineHCID 86594862HCID 86594862, compound

Product 1

HCID 86594861HCID 86594861, compound

Procedure

tert-Butyl (R)-[1-(4-aminophenyl)pyrrolidin-3-yl]methylcarbamate was reacted with carbonyldiimidazole and then with 4-(4-chlorophenyl)piperidine by method A. This resulted in the product with the molecular weight of 513.09 (C28H37CIN4O3); MS (ESI): 513 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 513.09 (C28H37CIN4O3)

Sources & evidence

ORD record
ord-1ae987e13830440a92740af262b4fe0a
Source dataset
uspto-grants-2011_06
Patent number
US07968550B2

Reaction notes

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