p-Fluoronitrobenzene → tert-butyl [(3R)-1-(4-nitrophenyl)pyrrolidin-3-yl]carbamate

HRID 2426613Notes

Reaction equation

HRID 2426613 reaction equation
[NH:1]1[CH2:5][CH2:4][C@@H:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])[CH2:2]1.F[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1>>[N+:21]([C:18]1[CH:19]=[CH:20][C:15]([N:1]2[CH2:5][CH2:4][C@@H:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:10])([CH3:12])[CH3:11])[CH2:2]2)=[CH:16][CH:17]=1)([O-:23])=[O:22]

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine

Product 1

HCID 86594863tert-butyl [(3R)-1-(4-nitrophenyl)pyrrolidin-3-yl]carbamate

Procedure

tert-Butyl (R)-pyrrolidin-3-ylcarbamate was reacted with 4-fluoronitro-benzene by method C. This resulted in the product with the molecular weight of 307.35 (C15H21N3O4); MS (ESI): 308 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 307.35 (C15H21N3O4)

Sources & evidence

ORD record
ord-35258c36fbeb4e8aa71665fef45abb96
Source dataset
uspto-grants-2011_06
Patent number
US07968550B2

Reaction notes

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