反应详情

A solution of tert-butyl (R)-methyl-[1-(4-nitrophenyl)pyrrolidin-3-yl]-carbamate (0.7 g) in dichloromethane (5 ml) was treated with trifluoroacetic acid (3 ml) for 1 hour. The reaction solution was concentrated and the residue was taken up in dichloromethane. After washing with sodium carbonate solution, the organic phase was dried over magnesium sulfate and concentrated. This resulted in the product with the molecular weight of 221.26 (C11H15N3O2); MS (ESI): 222 (M+H+).

1. concentrationThe reaction solution was concentrated
2. washAfter washing with sodium carbonate solution
3. dry with materialthe organic phase was dried over magnesium sulfate
4. concentrationconcentrated
5. customThis resulted in the product with the molecular weight of 221.26 (C11H15N3O2)