Aniline → HCID 21105558, compound

HRID 2426619Notes

Reaction equation

HRID 2426619 reaction equation
[NH:1]1[CH2:5][CH2:4][CH:3]([NH:6][C:7](=[O:9])[CH3:8])[CH2:2]1.F[C:11]1[CH:16]=CC([N+]([O-])=O)=[CH:13][CH:12]=1.[H][H].NC1C=CC=CC=1.[CH:29]1N=C[N:31]([C:34]([N:36]2C=N[CH:38]=[CH:37]2)=[O:35])[CH:30]=1.[CH:41]1([O:46][C:47]2[CH:53]=[CH:52]C(N)=C[CH:48]=2)[CH2:45][CH2:44][CH2:43][CH2:42]1>>[CH:41]1([O:46][C:47]2[CH:48]=[CH:38][C:37]([NH:36][C:34](=[O:35])[NH:31][C:30]3[CH:29]=[CH:13][C:12]([N:1]4[CH2:5][CH2:4][CH:3]([NH:6][C:7](=[O:9])[CH3:8])[CH2:2]4)=[CH:11][CH:16]=3)=[CH:52][CH:53]=2)[CH2:42][CH2:43][CH2:44][CH2:45]1

Participants

7

Reactant 6

HCID 6115AnilineHCID 9590p-FluoronitrobenzeneHCID 682631,1'-CarbonyldiimidazoleHCID 5227153-AcetamidopyrrolidineHCID 64844484-(cyclopentyloxy)anilineHCID 178418361HCID 178418361, compound

Product 1

HCID 21105558HCID 21105558, compound

Procedure

N-Pyrrolidin-3-ylacetamide was reacted with 4-fluoronitrobenzene, the resulting nitro compound was reduced with hydrogen and finally the aniline was reacted with CDI and 4-cyclopentyloxyaniline by method A, B and C. This resulted in the product with the molecular weight of 422.53 (C24H30N4O3); MS (ESI): 423 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 422.53 (C24H30N4O3)

Sources & evidence

ORD record
ord-ca2dc8bd26dd4344b6de49e393dbd68e
Source dataset
uspto-grants-2011_06
Patent number
US07968550B2

Reaction notes

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