1,1'-Carbonyldiimidazole → N-Methyl-N-(1-{4-[3-(4-piperidin-1-ylphenyl)ureido]phenyl}pyrrolidin-3-yl)acetamide

HRID 2426632Notes

Reaction equation

HRID 2426632 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]([CH3:17])[C:14](=[O:16])[CH3:15])[CH2:9]2)=[CH:4][CH:3]=1.[C:18](N1C=CN=C1)(N1C=CN=C1)=[O:19].[N:30]1([C:36]2[CH:41]=[CH:40][C:39]([NH2:42])=[CH:38][CH:37]=2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>>[CH3:17][N:13]([CH:10]1[CH2:11][CH2:12][N:8]([C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:18]([NH:42][C:39]3[CH:38]=[CH:37][C:36]([N:30]4[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]4)=[CH:41][CH:40]=3)=[O:19])=[CH:7][CH:6]=2)[CH2:9]1)[C:14](=[O:16])[CH3:15]

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 4135014-(Piperidin-1-yl)anilineHCID 21105566N-[1-(4-aminophenyl)pyrrolidin-3-yl]-N-methylacetamide

Product 1

HCID 21105625N-Methyl-N-(1-{4-[3-(4-piperidin-1-ylphenyl)ureido]phenyl}pyrrolidin-3-yl)acetamide

Procedure

N-[1-(4-Aminophenyl)pyrrolidin-3-yl]-N-methylacetamide was reacted with carbonyldiimidazole and then with 4-piperidin-1-ylphenylamine by method A. This resulted in the product with the molecular weight of 435.57 (C25H33N5O2); MS (ESI): 436 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 435.57 (C25H33N5O2)

Sources & evidence

ORD record
ord-770c5b6eea29458aa36603555d9b1874
Source dataset
uspto-grants-2011_06
Patent number
US07968550B2

Reaction notes

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