Butyl bromide → 1-(4-Butoxyphenyl)cyclopropanecarboxylic Acid {4-[3-(acetylmethylamino)-pyrrolidin-1-yl]phenyl}amide

HRID 2426641Notes

Reaction equation

HRID 2426641 reaction equation
[C:1]([CH2:4][NH:5][CH:6]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:20]3([C:23]4[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=4)[CH2:22][CH2:21]3)=[O:19])=[CH:13][CH:12]=2)[CH2:7]1)(=[O:3])[CH3:2].[CH2:30](Br)[CH2:31][CH2:32][CH3:33]>>[C:1]([CH2:4][NH:5][CH:6]1[CH2:10][CH2:9][N:8]([C:11]2[CH:12]=[CH:13][C:14]([NH:17][C:18]([C:20]3([C:23]4[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:25][CH:24]=4)[CH2:21][CH2:22]3)=[O:19])=[CH:15][CH:16]=2)[CH2:7]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 8002Butyl bromideHCID 865948711-(4-Hydroxyphenyl)cyclopropanecarboxylic Acid {4-[3-(acetylmethylamino)pyrrolidin-1-yl]phenyl}amide

Product 1

HCID 865948701-(4-Butoxyphenyl)cyclopropanecarboxylic Acid {4-[3-(acetylmethylamino)-pyrrolidin-1-yl]phenyl}amide

Procedure

1-(4-Hydroxyphenyl)cyclopropanecarboxylic acid {4-[3-(acetylmethyl -amino)pyrrolidin-1yl]phenyl}amide was reacted with n-butyl bromide by method H. This resulted in the product with the molecular weight of 449.60 (C27H35N3O3); MS(ESI): 450 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 449.60 (C27H35N3O3)

Sources & evidence

ORD record
ord-bcfab6ff144d4240ac65e5fa4ab292ab
Source dataset
uspto-grants-2011_06
Patent number
US07968550B2

Reaction notes

Loading…