HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-(5-Chloropyridin-2-yloxy)-N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,5-Dichloropyridine | HCID 27685 | — |
| Reactant | N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]-4-hydroxybenzamide | HCID 21105609 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(5-Chloropyridin-2-yloxy)-N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]benzamide | HCID 21105466 | — |
Reaction Steps
A solution of 0.05 g of N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]-4-hydroxybenzamide, 0.017 g of 2,5-dichloropyridine and 0.064 g of potassium carbonate in 0.8 ml of DMF was heated at 230° C. in a microwave apparatus for 30 minutes. The solution was filtered and purified by preparative HPLC. This resulted in the product with the molecular weight of 436.17 (C24H25CIN4O2); MS (ESI): 437 (M+H+) as hydrotrifluoroacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968550B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-46bfdc27c9954a1dabcf5cdc7928fb91 |
| Source note | uspto-grants-2011_06 |