反应详情

A solution of 0.05 g of N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]-4-hydroxybenzamide, 0.017 g of 2,5-dichloropyridine and 0.064 g of potassium carbonate in 0.8 ml of DMF was heated at 230° C. in a microwave apparatus for 30 minutes. The solution was filtered and purified by preparative HPLC. This resulted in the product with the molecular weight of 436.17 (C24H25CIN4O2); MS (ESI): 437 (M+H+) as hydrotrifluoroacetate.

1. filtrationThe solution was filtered
2. custompurified by preparative HPLC
3. customThis resulted in the product with the molecular weight of 436.17 (C24H25CIN4O2)