HCID 86613210, compound → HCID 86613209, compound

HRID 2426800Notes

Reaction equation

HRID 2426800 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[F:8][C:9]([F:14])([F:13])[C:10]([O-:12])=[O:11].C([NH+:22]([CH2:29][CH:30]1[CH2:32][CH:31]1[CH3:33])[CH2:23][CH2:24][CH2:25][NH+:26]([CH3:28])[CH3:27])C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[F:8][C:9]([F:14])([F:13])[C:10]([O-:12])=[O:11].[CH3:28][NH+:26]([CH3:27])[CH2:25][CH2:24][CH2:23][NH2+:22][CH2:29][CH:30]1[CH2:32][CH:31]1[CH3:33]

Participants

4

Reactant 1

HCID 86613210HCID 86613210, compound

Product 1

HCID 86613209HCID 86613209, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

A solution of N1-benzyl-N3,N3-dimethyl-N1-[(2-methylcyclopropyl)methyl]propane-1,3-diaminium bis(trifluoroacetate) (0.42 g, 0.86 mmol) in ethanol (50 mL) was degassed with nitrogen and treated with palladium hydroxide (75 mg). The reaction was placed under a hydrogen atmosphere and stirred vigorously for 1 hour. The reaction was filtered through celite, washed with methanol and concentrated in vacuo to give N,N-dimethyl-N′-[(2-methylcyclopropyl)methyl]propane-1,3-diaminium bis(trifluoroacetate) as a pale yellow oil.

Workup

  1. filtrationThe reaction was filtered through celite
  2. washwashed with methanol
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-295b07198a7e449e84e9d947aa373d15
Source dataset
uspto-grants-2011_06
Patent number
US07968571B2

Reaction notes

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