Potassium Fluoride → HCID 86612138, compound

HRID 2426850Notes

Reaction equation

HRID 2426850 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]([CH3:14])[CH:7]=[C:6]2[C:15]#[C:16][Si](C)(C)C.[F-].[K+]>CO>[C:15]([C:6]1[C:5]2[C:9](=[CH:10][C:11]([O:12][CH3:13])=[C:3]([O:2][CH3:1])[CH:4]=2)[N:8]([CH3:14])[CH:7]=1)#[CH:16]

Participants

4

Reactant 2

HCID 522689Potassium FluorideHCID 67147798HCID 67147798, compound

Product 1

HCID 86612138HCID 86612138, compoundYield 78.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

But using 1.71 g of 5,6-dimethoxy-1-methyl-3-trimethylsilanylethynyl-1H-indole and 1.04 g of potassium fluoride in 70 ml of methanol. 1 g of 3-ethynyl-5,6-dimethoxy-1-methyl-1H-indole is thus obtained in the form of a solid, the characteristics of which are as follows:

Sources & evidence

ORD record
ord-e31548dbf297404fa463aea91753632d
Source dataset
uspto-grants-2011_06
Patent number
US07968566B2

Reaction notes

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