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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2427133Generated: November 1, 2026

2-Bromo-1-(4-fluorophenyl)ethan-1-one → 1-(4-Fluorophenyl)-2-hydroxyethanone

https://huagongshe.com/reaction/2427133

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-1-(4-fluorophenyl)ethan-1-oneHCID 96749—
ReactantSodium FormateHCID 2723810—
SolventWater ethanolHCID 19096565—
Product1-(4-Fluorophenyl)-2-hydroxyethanoneHCID 2810715—

Reaction Steps

2 g of 2-bromo-1-(4-fluorophenyl)ethanone, and 6 eq of sodium formate in 15 mL of Ethanol/Water are irradiated under microwave for 5 min at 150° C., 11 bars. After filtration and evaporation of ethanol, water is added. The expected product is isolated by filtration

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07968581B2
Source datasetuspto-grants-2011_06
ORD IDord-c1351e08a2a445c59044b8eac9d0b8b5
Source noteuspto-grants-2011_06