2-Bromo-1-(4-fluorophenyl)ethan-1-one → 1-(4-Fluorophenyl)-2-hydroxyethanone

HRID 2427133Notes

Reaction equation

HRID 2427133 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].C([O-])=[O:13].[Na+]>C(O)C.O>[F:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][OH:13])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 967492-Bromo-1-(4-fluorophenyl)ethan-1-oneHCID 2723810Sodium Formate

Product 1

HCID 28107151-(4-Fluorophenyl)-2-hydroxyethanone

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

2 g of 2-bromo-1-(4-fluorophenyl)ethanone, and 6 eq of sodium formate in 15 mL of Ethanol/Water are irradiated under microwave for 5 min at 150° C., 11 bars. After filtration and evaporation of ethanol, water is added. The expected product is isolated by filtration

Workup

  1. filtrationAfter filtration and evaporation of ethanol, water
  2. additionis added

Sources & evidence

ORD record
ord-c1351e08a2a445c59044b8eac9d0b8b5
Source dataset
uspto-grants-2011_06
Patent number
US07968581B2

Reaction notes

Loading…