Water → HCID 22148907, compound

HRID 2427194Notes

Reaction equation

HRID 2427194 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N+:19]([O-])=O)[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.[NH4+].[Cl-].O>CCO.[Fe]>[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2

Participants

6

Reactant 3

HCID 962WaterHCID 25517Ammonium ChlorideHCID 23503311HCID 23503311, compound

Product 1

HCID 22148907HCID 22148907, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 702EthanolSolvent

Procedure

To a solution of nitrobenzene 198 (2.07 g) and NH4Cl (1.84 g) in EtOH (40 ml)-H2O (10 ml), was added iron powder (1.92 g). The mixture was heated to reflux for 1 hr. After cooling the reaction mixture was filtered through short celite pad. The filtrate was concentrated, diluted with sat. NaHCO3 (30 ml) and extracted with AcOEt (30 ml). The combined organic layers were washed with brine (30 ml) and dried over Na2SO4. Concentration of the solvent afforded the aniline 199 (1.77 g, 95%) as a yellow solid.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 1 hr
  3. temperatureAfter cooling the reaction mixture
  4. filtrationwas filtered through short celite pad
  5. concentrationThe filtrate was concentrated
  6. additiondiluted with sat. NaHCO3 (30 ml)
  7. extractionextracted with AcOEt (30 ml)
  8. washThe combined organic layers were washed with brine (30 ml)
  9. dry with materialdried over Na2SO4

Sources & evidence

ORD record
ord-a34cd17e35dc4c409470bee9e0e0062f
Source dataset
uspto-grants-2011_06
Patent number
US07968567B2

Reaction notes

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