反应详情

温度

40 °C

Heat a mixture of 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1,2,3,4-tetrahydro-cyclopenta[b]indole-7-carbonitrile (5 g, 15.3 mmol) in DMF (25 ml) to 40° C. Add cesium carbonate (10.4 g, 32.4 mmol) and 2-bromomethylpyridine hydrobromide (4.05 g, 16 mmol). Stir the mixture at 40° C. for 24 h. Add the mixture to water (250 mL) and stir for 1 h. Filter the solids and dry the collected material under vacuum. Add the solid to ethanol (25 mL) and reflux for 30 min. Cool the mixture to 22° C. and filter. Dry the solid under vacuum to constant weight to provide 4.8 g (75%) of the title compound. MS (m/z): 419 (M+1).

1. temperatureHeat
2. stirringstir for 1 h
3. filtrationFilter the solids
4. customdry the collected material under vacuum
5. additionAdd the solid to ethanol (25 mL)
6. temperaturereflux for 30 min
7. temperatureCool the mixture to 22° C.
8. filtrationfilter
9. customDry the solid under vacuum to constant weight