Hydrochloric Acid → HCID 67251326, compound

HRID 2427275Notes

Reaction equation

HRID 2427275 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:27][C:11]2[N:12]([CH2:21][C:22]3[CH:26]=[CH:25][S:24][N:23]=3)[C:13]3[CH:14]=[CH:15][C:16]([C:19]#[N:20])=[CH:17][C:18]=3[C:10]=2[CH2:9]1)(C)(C)C.[ClH:29]>O1CCOCC1>[ClH:29].[ClH:29].[NH2:7][C@H:8]1[CH2:27][C:11]2[N:12]([CH2:21][C:22]3[CH:26]=[CH:25][S:24][N:23]=3)[C:13]3[CH:14]=[CH:15][C:16]([C:19]#[N:20])=[CH:17][C:18]=3[C:10]=2[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67252920HCID 67252920, compound

Product 1

HCID 67251326HCID 67251326, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Stir a suspension of (R)-(7-cyano-4-isothiazol-3-ylmethyl-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl)-carbamic acid tert-butyl ester (1.16 g, 3.19 mmol) in 4M HCl in dioxane (20 mL) for 2 h at room temperature, then concentrate in vacuo. Dry the residue under vacuum overnight at 40° C. MS (m/z): 295 (M+1).

Workup

  1. concentrationconcentrate in vacuo
  2. customDry the residue under vacuum overnight at 40° C

Sources & evidence

ORD record
ord-6a91567df3334a8e810e9e465ef0bedd
Source dataset
uspto-grants-2011_06
Patent number
US07968587B2

Reaction notes

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