反应详情

A reaction mixture of 4-methyl-1-(4-methylbenzyl)-3-p-tolyl-1H-pyrrole-2-carboxylic acid ethyl ester (550 mg, 1.58 mmol) and NaOH (1.26 g, 32 mmol) in MeOH (45 mL) and H2O (15 mL) was refluxed for 1 h. After removal of the solvent, aqueous 1N NaOH (100 mL) was added and extraction performed with EtOAc (2×20 mL). After drying of the combined organic phases over Na2SO4, filtration and removal of the solvent, the desired product 4-methyl-1-(4-methylbenzyl)-3-p-tolyl-1H-pyrrole-2-carboxylic acid was obtained, which was used without further purification.

1. temperaturewas refluxed for 1 h
2. customAfter removal of the solvent, aqueous 1N NaOH (100 mL)
3. additionwas added
4. extractionextraction
5. dry with materialAfter drying of the combined organic phases over Na2SO4, filtration and removal of the solvent