Sodium Hydroxide → 4-methyl-1-(4-methylbenzyl)-3-p-tolyl-1H-pyrrole-2-carboxylic acid

Participants

Reaction Steps

A reaction mixture of 4-methyl-1-(4-methylbenzyl)-3-p-tolyl-1H-pyrrole-2-carboxylic acid ethyl ester (550 mg, 1.58 mmol) and NaOH (1.26 g, 32 mmol) in MeOH (45 mL) and H2O (15 mL) was refluxed for 1 h. After removal of the solvent, aqueous 1N NaOH (100 mL) was added and extraction performed with EtOAc (2×20 mL). After drying of the combined organic phases over Na2SO4, filtration and removal of the solvent, the desired product 4-methyl-1-(4-methylbenzyl)-3-p-tolyl-1H-pyrrole-2-carboxylic acid was obtained, which was used without further purification.

Provenance & Evidence