Methanol → Methyl 2-iodo-6-methylbenzoate

HRID 2427580ノート

反応式

HRID 2427580 の反応式
[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([OH:6])=[O:5].[C:12](Cl)(=O)C(Cl)=O.CO.C(N(CC)CC)C>ClCCl.CN(C)C=O>[CH3:12][O:5][C:4](=[O:6])[C:3]1[C:7]([CH3:11])=[CH:8][CH:9]=[CH:10][C:2]=1[I:1]

参加物

7

反応物 4

HCID 887MethanolHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 98565312-Iodo-6-methylbenzoic acid

生成物 1

HCID 23655277Methyl 2-iodo-6-methylbenzoate

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-iodo-6-methyl-benzoic acid (3.42 g, 13 mmol) in dichloromethane (25 mL) was treated with oxalyl chloride (7.5 mL, 15 mmol) and dimethylformamide (several drops) followed by treatment with methanol (30 mL) and triethylamine (2.78 mL, 20 mmol). Workup afforded 2-iodo-6-methyl-benzoic acid methyl ester. The material was used without further purification.

出典と根拠

ORDレコード
ord-6f594cd6fe804ba99c6007f416d0a69b
出典データセット
uspto-grants-2011_06
特許番号
US07968570B2

反応ノート

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