Methanol → HCID 54596450, compound

HRID 2427789Notes

Reaction equation

HRID 2427789 reaction equation
[Na].[Br:2][C:3]1[C:4](=[O:18])[N:5]([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[C:12]([Cl:17])[CH:11]=2)[N:6]=[CH:7][C:8]=1Br.[CH3:19][OH:20]>>[Br:2][C:3]1[C:4](=[O:18])[N:5]([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[C:12]([Cl:17])[CH:11]=2)[N:6]=[CH:7][C:8]=1[O:20][CH3:19]

Participants

4

Reactant 3

HCID 887Methanol2×HCID 5360545SodiumHCID 67148709HCID 67148709, compound

Product 1

HCID 54596450HCID 54596450, compound

Procedure

Sodium (0.28 g, 0.012 moles) was dissolved in methanol (100 ml) and a suspension of 4,5-Dibromo-2-(3,5-dichlorophenyl)pyridazin-3-one (4.0 g, 0.01 moles) in methanol (60 ml) was added. Refluxed overnight. Evaporated to dryness and added water. Filtered off the solid and dried in a dessicator. Triturated with ether and dried in a dessicator. (3.1 g, 89%)

Workup

  1. additionwas added
  2. temperatureRefluxed overnight
  3. customEvaporated to dryness
  4. additionadded water
  5. filtrationFiltered off the solid
  6. customdried in a dessicator
  7. customTriturated with ether
  8. customdried in a dessicator

Sources & evidence

ORD record
ord-533585ac5cdf47dda87e72f458eb7fa0
Source dataset
uspto-grants-2011_06
Patent number
US07968711B2

Reaction notes

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