反应详情

A mixture of (5-fluoro-2-nitrophenyl)phenylamine (1.37 g, 5.90 mmol) in IMS (50 mL) and EtOAc (50 mL) was degassed with a stream of nitrogen prior to addition of 10% Pd/C (138 mg) and was stirred at RT under a hydrogen atmosphere for 4 h. The suspension was then filtered through a PTFE frit and the filtrate was concentrated in vacuo affording 4-Fluoro-N2-phenylbenzene-1,2-diamine as a red oil (1.19 g, quantitative). LCMS: RT 2.87 min [M+H]+ 203.1.

1. customwas degassed with a stream of nitrogen
2. additionto addition of 10% Pd/C (138 mg)
3. filtrationThe suspension was then filtered through a PTFE frit
4. concentrationthe filtrate was concentrated in vacuo