1,1'-Carbonyldiimidazole → HCID 57474620, compound

HRID 2427972Notes

Reaction equation

HRID 2427972 reaction equation
[CH:1]([N:4]1[C:12](=[O:13])[NH:11][C:10]2[C:5]1=[N:6][C:7]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([OH:23])[CH:18]=1)=[N:8][C:9]=2[C:14]([O-:16])=O)([CH3:3])[CH3:2].[NH2:24]C1C(C([O-])=O)=NC(C2C=CC=C(O)C=2)=NC=1NC(C)C.C(N1C=CN=C1)(N1C=CN=C1)=O>>[CH:1]([N:4]1[C:12](=[O:13])[NH:11][C:10]2[C:5]1=[N:6][C:7]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([OH:23])[CH:18]=1)=[N:8][C:9]=2[C:14]([NH2:24])=[O:16])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 178456606HCID 178456606, compoundHCID 178456837HCID 178456837, compound

Product 1

HCID 57474620HCID 57474620, compoundYield 63%

Procedure

9-Isopropyl-2-(3-hydroxy-phenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxylate. 5-Amino-6-isopropylamino-2-(3-hydroxy-phenyl)-pyrimidine-4-carboxylate (0.43 g, 1.4 mmol) and 1,1′-carbonyldiimidazole (1.1 g, 6.8 mmol) were reacted according to General Procedure F. The crude residue was triturated with methylene chloride and cold hexanes to afford the title compound as a white solid (0.29 g, 0.85 mmol, 63% yield). MS (ESI) m/z 343.4 [M+1]+.

Workup

  1. customThe crude residue was triturated with methylene chloride and cold hexanes

Sources & evidence

ORD record
ord-fbaa7cd9d26a4cf1975f634816867b06
Source dataset
uspto-grants-2011_06
Patent number
US07968556B2

Reaction notes

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