Trifluoroacetic acid → HCID 66647723, compound

HRID 2428006Notes

Reaction equation

HRID 2428006 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:17](=[O:18])[NH:16][C:15]2[C:10]1=[N:11][C:12]([NH:24][CH2:25][C@@H:26]1[CH2:30][CH2:29][CH2:28][NH:27]1)=[N:13][C:14]=2[C:19]([O:21]CC)=O.C(OC([N:38]1CCC[C@H]1CNC1N=C2C(NC(=O)N2C2C=CC=CC=2OC)=C(C(OCC)=O)N=1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:17](=[O:18])[NH:16][C:15]2[C:10]1=[N:11][C:12]([NH:24][CH2:25][C@@H:26]1[CH2:30][CH2:29][CH2:28][NH:27]1)=[N:13][C:14]=2[C:19]([NH2:38])=[O:21]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 86627721HCID 86627721, compoundHCID 86627722HCID 86627722, compound

Product 1

HCID 66647723HCID 66647723, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(S)-Ethyl 9-(2-methoxyphenyl)-8-oxo-2-(pyrrolidin-2-ylmethylamino)-8,9-dihydro-7H-purine-6-carboxylate. (S)-Ethyl 2-((1-(tert-butoxycarbonyl)pyrrolidin-2-yl)methylamino)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxylate (0.352 g, 0.687 mmol) was dissolved in dichloromethane (3 mL) and trifluoroacetic acid (1 mL) was added. The solution was stirred for two h and condensed under reduced pressure to afford the crude title compound (0.400 g, >100%). MS (ESI) m/z 413.1 [M+1]+.

Sources & evidence

ORD record
ord-cfd8b92712c94768a6b5c207e4025bf2
Source dataset
uspto-grants-2011_06
Patent number
US07968556B2

Reaction notes

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